Neutralizing anti-influenza binding molecules and uses thereof

An isolated binding molecule which specifically binds to influenza A virus and influenza B virus, comprising:

• (a) a first binding domain that is capable of binding to influenza A virus hemagglutinin (HA) and neutralizing at least one group 1 subtype and at least 1 group 2 subtype of influenza A virus, wherein the first binding domain includes a set of six CDRs:
• HCDR1, HCDR2, HCDR3, LCDR1, LCDR2, LCDR3 in which the set of six CDRs has an amino acid sequence selected from:
• (i) an amino acid sequence of:
• HCDR1 of SEQ ID NO.:
• 8, HCDR2 of SEQ ID NO.:
• 9, HCDR3 of SEQ ID NO.:
• 10, LCDR1 of SEQ ID NO.:
• 3, LCDR2 of SEQ ID NO.:
• 4 and LCDR3 of SEQ ID NO.:
• 5;
• and
• (ii) an amino acid sequence of:
• HCDR1 of SEQ ID NO.:
• 18, HCDR2 of SEQ ID NO.:
• 19, HCDR3 of SEQ ID NO.:
• 20, LCDR1 of SEQ ID NO.:
• 13, LCDR2 of SEQ ID NO.:
• 14, LCDR3 of SEQ ID NO.:
• 15;
• and
• (b) a second binding domain that is capable of binding to influenza B virus hemagglutinin (HA) and neutralizing influenza B virus in at least two phylogenetically distinct lineages, wherein the second binding domain includes a set of six CDRs:
• HCDR1, HCDR2, HCDR3, LCDR1, LCDR2, LCDR3 in which the set of six CDRs has an amino acid sequence selected from:
• (i) an amino acid sequence of:
• HCDR1 of SEQ ID NO.:
• 28, HCDR2 of SEQ ID NO.:
• 29, HCDR3 of SEQ ID NO.:
• 30, LCDR1 of SEQ ID NO.:
• 23, LCDR2 of SEQ ID NO.:
• 24 and LCDR3 of SEQ ID NO.:
• 25;
• (ii) an amino acid sequence of:
• HCDR1 of SEQ ID NO.:
• 44, HCDR2 of SEQ ID NO.:
• 45, HCDR3 of SEQ ID NO.:
• 46, LCDR1 of SEQ ID NO.:
• 39, LCDR2 of SEQ ID NO.:
• 40 and LCDR3 of SEQ ID NO.:
• 41;
• and
• (iii) an amino acid sequence of:
• HCDR1 of SEQ ID NO.:
• 60, HCDR2 of SEQ ID NO.:
• 61, HCDR3 of SEQ ID NO.:
• 62, LCDR1 of SEQ ID NO.:
• 55, LCDR2 of SEQ ID NO.:
• 56, LCDR3 of SEQ ID NO.:
• 57.