Nucleic acid encoding angiopoietin-2 specific Tie2 receptor
AssigneeUnited Kingdom Research and Innovation
InventorsNicolas Phillip James Brindle, Julian Edward Sale
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Abstract
In one aspect, provided herein is a polypeptide comprising a modified angiopoietin receptor or fragment thereof, wherein the polypeptide binds preferentially to angiopoietin-2 compared to angiopoeitin-1. Nucleic acid sequences encoding the polypeptide, as well as pharmaceutical uses of the polypeptide in treating diseases such as cancer and inflammation are also provided.
Claims4
A nucleic acid comprising a nucleotide sequence encoding a polypeptide, wherein the polypeptide comprises a modified angiopoietin receptor or fragment thereof, wherein the fragment comprises a sequence corresponding to residues 23-210 of SEQ ID NO:
- 1, wherein the polypeptide binds preferentially to angiopoietin-2 compared to angiopoietin-1;
- wherein the angiopoietin receptor is Tie2;
- and wherein the polypeptide comprises the following mutations with respect to SEQ ID NO:
- 1 or SEQ ID NO:
- 2:
- (i) F161I, ΔR167 and ΔH168, or
- (ii) F161G, ΔR167 and ΔH168.
Dependencies are inferred from the claim text.