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US 10,882,893 B2Granted
TMIGD2 and its derivatives as blockers or binders of cancer-expressed HHLA2 for immunotherapies
AssigneeAlbert Einstein College of Medicine
InventorsXingxing Zang, Jordan M. Chinai, Murali Janakiram, Steven C. Almo, Andras Fiser
Life of this patent
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Abstract
Provided are methods of treating an HHLA2-bearing tumor in a subject with a fusion protein comprising an IgV-like domain of a TMIGD2 sufficient to treat the HHLA2-bearing tumor. A fusion protein comprising an IgV-like domain of a TMIGD2 and related compositions and encoding nucleic acids are also provided.
Claims6
An isolated fusion protein comprising an IgV-like domain of a TMIGD2 and an Fc portion of an immunoglobulin G, wherein the isolated fusion protein comprises SEQ ID NO:2 or SEQ ID NO:3.
Dependencies are inferred from the claim text.