Papillomavirus chimeric protein and application thereof

A chimeric papillomavirus protein, comprising:

• a papillomavirus HPV16 L1 protein or a mutant of the papillomavirus HPV16 L1 protein as a scaffold;
• and at least one polypeptide from a HPV33 L2 protein or from a mutant of the HFV33 L2 protein inserted into the scaffold, wherein
• the at least one polypeptide is shown as SEQ ID NO:
• 1, SEQ ID NO:
• 2, SEQ ID NO:
• 3, SEQ ID NO:
• 5, or SEQ ID NO:
• 6,
• the at least one polypeptide is inserted into a surface region of the HPV16 L1 protein or the mutant of the HPV16 L1 protein, and
• the at least one polypeptide is selected from the group consisting of:
• the polypeptide from the HPV33 L2 protein shown as SEQ ID NO:
• 1 or SEQ ID NO:
• 2 is inserted into the HPV16 L1 protein or the mutant of the HPV16 L1 protein between amino acid positions 136 and 137,
• after deletion of amino acid 135-138 region from the HPV16 L1 protein or the mutant of the HPV16 L1 protein, the polypeptide from the HPV33 L2 protein shown as SEQ ID NO:
• 5 or SEQ ID NO:
• 6 is inserted into the HPV16 L1 protein or the mutant of the HPV16 L1 protein between amino acid positions 134 and 139, and
• after deletion of amino acid 431-432 region from the HPV16 L1 protein or the mutant of the HPV16 L1 protein, the polypeptide from the HPV33 L2 protein shown as SEQ ID NO:
• 2 or SEQ ID NO:
• 3 is inserted into the HPV16 L1 protein or the mutant of the HPV16 L1 protein between amino acid positions 430 and 433.