Adeno-associated virus polynucleotides, polypeptides and virions
AssigneesChildren's Medical Research Institute, The Sydney Children's Hospitals Network (Randwick and Westmead) (Incorporating the Royal Alexandra Hospital for Children), The United States of America, AS Represented By the Secretary, Department of Health and Human Services (Washington Dc)
InventorsClaus Hallwirth, Ian Alexander, Richard Smith, Robert Kotin
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Abstract
Polypeptides are encoded by an adeno-associated virus (AAV)-derived endogenous viral element (mAAV-EVE1) found within the germline of numerous closely-related marsupial species. Nucleic acid molecules encode the polypeptides. Vectors can include the nucleic acid molecules, and recombinant AAV virions can include the polypeptides. A chimeric capsid protein can also include an MAAV-EVE1 polypeptide.
Claims21
An isolated capsid polypeptide, comprising a sequence having at least 95% sequence identity to the sequence set forth in SEQ ID NO:2.
Dependencies are inferred from the claim text.