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US 10,882,885 B2Granted
Peptide-based synthetic molecules and silica nanostructures
AssigneeMassachusetts Institute of Technology
InventorsAndrea Kimi Wallace, Maiko Furubayashi, Christopher A. Voigt
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Abstract
Described herein are novel synthetic molecules, polymers, and compositions comprising silica-binding peptides, and their methods of production. Also described herein are methods of synthesizing structurally and chemically complex silica-based materials using the synthetic molecules, polymers, and compositions.
Claims20
A synthetic molecule comprising or consisting essentially of the amino acid sequence of SEQ ID NO:
- 1, wherein at least one amino acid of SEQ ID NO:
- 1 contains a non-native post-translational modification selected from the group consisting of oxidation, myristoylation, hypusination, and methylation, wherein the methylation occurs at Lys3, Lys4, and/or Lys15 of SEQ ID NO:
- 1.
A synthetic molecule comprising:
- a silica binding protein comprising the amino acid sequence of SEQ ID NO:
- 1, wherein at least one amino acid of SEQ ID NO:
- 1 contains a non-native post-translational modification selected from the group consisting of oxidation, myristoylation, hypusination, and methylation, wherein the methylation occurs at Lys3, Lys4, and/or Lys15 of SEQ ID NO:
- 1;
- and a terminal fusion molecule, wherein the terminal fusion molecule is:
- (i) a metal-binding polypeptide, a magnetosome surface polypeptide, or a carbon-nanotube-binding polypeptide;
- and
- (ii) fused to at least one terminal end of the silica-binding peptide.
5 more elements
Dependencies are inferred from the claim text.