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US 10,882,884 B2Granted
Stereoselective synthesis of phosphorothioate oligoribonucleotides
AssigneeETH Zurich
InventorsJonathan Hall, Meiling Li
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Abstract
The present invention relates to chiral phosphoramidites represented by formula (Ia) or formula (Ib) as novel monomers for the synthesis of stereodefined phosphorothioate MOE oligonucleotides. Furthermore, the present invention relates to a method for synthesizing stereodefined phosphorothioate MOE oligonucleotides using said novel chiral phosphoramidites.
Claims30
A compound of formula (Ia) or formula (Ib),
- wherein Ar is phenyl (Ph, C6H5) optionally substituted with:
- halogen, C1-C6alkyl, C3-C6cycloalkyl, or C1-C4alkoxy;
- and R is a protective group of a hydroxyl group;
- and Bn is selected from (i) adenine, (ii) cytosine, (iii) 5-methylcytosine, (iv) guanine, (v) uracil, (vi) 5-methyluracil, or (vii) a derivative of (i), (ii), (iii), (iv), (v) or (vi).
1 more element
Dependencies are inferred from the claim text.