Heterocyclic compounds and use thereof

A compound of formula (I):

• wherein
• each of R1 and R2, independently, is H, halo, NO2, CN, NH2, C1-6 alkyl, C1-6 alkoxyl, C3-10 cycloalkyl, C1-10 heterocycloalkyl, aryl, or heteroaryl;
• or R1 and R2, together with the two carbon atoms to which they are bonded, are C5-10 cycloalkyl, C3-10 heterocycloalkyl, aryl, or heteroaryl, each of the C1-6 alkyl, C1-6 alkoxyl, C3-10 cycloalkyl, C1-10 heterocycloalkyl, C5-10 cycloalkyl, C3-10 heterocycloalkyl, aryl, and heteroaryl being optionally substituted with halo, NO2, CN, NH2, C1-6 alkyl, C1-6 alkoxyl, aryl, heteroaryl, or C(O)ORa, in which Ra is H, C1-10 alkyl, C3-10 cycloalkyl, C3-10 heterocycloalkyl, aryl, or heteroaryl;
• and each of R3 and R4, independently, is
• in which at least one of R3 and R4 is
• R5 is H, C1-6 alkyl, C3-10 cycloalkyl, C1-10 heterocycloalkyl, aryl alkyl, heteroaryl alkyl, aryl, or heteroaryl, each of the C1-6 alkyl, C3-10 cycloalkyl, C1-10 heterocycloalkyl, aryl alkyl, heteroaryl alkyl, aryl, and heteroaryl being optionally substituted with halo, nitro, cyano, amino, C1-6 alkyl, C1-6 alkoxyl, C3-10 cycloalkyl, C1-10 heterocycloalkyl, aryl, or heteroaryl;
• R6 is deleted, H, C1-6 alkyl, C1-6 alkoxyl, C3-10 cycloalkyl, C1-10 heterocycloalkyl, aryl, or heteroaryl, each of the C1-6 alkyl, C1-6 alkoxyl, C3-10 cycloalkyl, C1-10 heterocycloalkyl, aryl, and heteroaryl being optionally substituted with hydroxy, hydroxy C1-6 alkyl, halo, nitro, cyano, or amino;
• R7 is H, C1-6 alkyl, C1-6 alkoxyl, C3-10 cycloalkyl, C1-10 heterocycloalkyl, aryl, or heteroaryl, each of the C1-6 alkyl, C1-6 alkoxyl, C3-10 cycloalkyl, C1-10 heterocycloalkyl, aryl, and heteroaryl being optionally substituted with hydroxy, hydroxy C1-6 alkyl, halo, nitro, cyano, amino, amino C1-6 alkyl, amino C3-10 cycloalkyl, amino C1-10 heterocycloalkyl, C3-10 cycloalkyl, C1-10 heterocycle, aryl, or heteroaryl;
• each of A and B in
• independently, is C or N;
• and each of D, E and F in
• independently, is C, N, O, or S;
• in which when B is C and R3 is
• then at least one of D and E is C, O, or S;
• and when B is N and R3 is
• then D is N;
• and
• each of L1 and L2, independently, is heteroaryl, C1-10 heterocycloalkyl, or NRd, in which Rd is H or C(O)(CH2)2CHNH2CO2Re, Re being H, C1-6 alkyl, C3-10 cycloalkyl, C3-10 heterocycloalkyl, aryl, or heteroaryl;
• each of m, n, and o, independently, is 1, 2, 3, 4, 5, or 6;
• each of R8 and R9, independently, is H, C1-6 alkyl, C3-10 cycloalkyl, C1-10 heterocycloalkyl, aryl, or heteroaryl, each of the C1-6 alkyl, C3-10 cycloalkyl, C1-10 heterocycloalkyl, aryl, and heteroaryl being optionally substituted with C(O)ORf, in which Rf is H, C1-10 alkyl, C3-20 cycloalkyl, C3-20 heterocycloalkyl, aryl, or heteroaryl;
• or R8 and R9, together with the nitrogen atoms to which they are bonded, are C3-10 heterocycloalkyl;
• L3 is C1-6 alkyl;
• or L3, together with R8 or R9 and the nitrogen atom to which they are bonded, is C4-10 heterocycloalkyl or heteroaryl;
• and
• R10 is H, C1-6 alkyl, C1-6 alkoxyl, C3-10 cycloalkyl, C1-10 heterocycloalkyl, aryl, heteroaryl, or
• in which L4 is deleted or C1-6 alkylamino;
• L5 is C1-6 alkyl, C1-6 alkylamino, or di-C1-6 alkylamino;
• and R11 is hydroxyl or C1-6 alkylamino;
• each of the C1-6 alkyl, C1-6 alkoxyl, C3-10 cycloalkyl, C1-10 heterocycloalkyl, C1-6 alkylamino;
• di-C1-6 alkylamino, aryl, and heteroaryl being optionally substituted with hydroxyl, amino, C(O)OR12, or P(O)(OR13)2, in which each of R12 and R13, independently, is H or C1-6 alkyl.