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US 10,882,849 B2Granted
Dimeric contrast agents
AssigneeBracco Imaging S.P.A.
InventorsValeria Boi, Roberta Napolitano, Luciano Lattuada
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Abstract
The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
Claims8
A compound having the following formula (II)
- in which:
- m is 1, 2, 3, 4, 5, or 6;
- n is 1 or 2;
- and
- R2 is a group of formula —(CH2)sCH(R3)-G
- in which
- s is 0, 1 or 2
- R3 is H, or an arylalkylene or cycloalkyl-alkylene having from 1 up to 3 carbon atoms in the alkylene chain;
- G is a group selected from —PO(OR4)2, —PO(R5)(OR4) and —COOH;
- in which
- R4 independently of one another is H or C1-C5 alkyl;
- R5 is an aryl or a cyclohexyl ring, or C1-C5 alkyl which is optionally substituted by an aryl or cyclohexyl ring
- or a physiologically acceptable salt thereof.
10 more elements
Dependencies are inferred from the claim text.