Inhibitors of KRAS G12C mutant proteins

A compound having the following structure (Ia′):

• or a pharmaceutically acceptable salt, tautomer, stereoisomer or prodrug thereof, wherein:
• G1, G2 and G4 are each N;
• G3 is CR, where R is H;
• R2a and R2b are each independently H, halo, hydroxyl, cyano, aminocarbonyl, formyl, C1-C6 alkyl, C1-C6 alkylsulfonyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, C1-C6 alkoxy, C1-C6 hydroxylalkyl, C1-C6 alkoxyalkyl, C1-C6 aminoalkyl, aliphatic heterocyclyl, heteroaryl or aryl;
• R2c is haloalkylaminyl, alkylcarbonylaminyl, haloalkylcarbonylaminyl or heteroarylaminyl;
• R3a and R3b are, at each occurrence, independently H, —OH, —NH2, —CO2H, halo, cyano, C1-C6 alkyl, C2-C6 alkynyl, hydroxylalkyl, aminylalkyl, alkylaminylalkyl, cyanoalkyl, carboxyalkyl, aminocarbonylalkyl or aminocarbonyl;
• or one R3a and one R3b join to form a carbocyclic or heterocyclic ring, and each remaining R3a and R3b are, at each occurrence, independently H, —OH, —NH2, —CO2H, halo, cyano, C1-C6 alkyl, C2-C6 alkynyl, hydroxylalkyl, aminylalkyl, alkylaminylalkyl, cyanoalkyl, carboxyalkyl, aminocarbonylalkyl or aminocarbonyl;
• or one R3b joins with one R4b to form a carbocyclic or heterocyclic ring, and each R3a and each remaining R3b are, at each occurrence, independently H, —OH, —NH2, —CO2H, halo, cyano, C1-C6 alkyl, C2-C6 alkynyl, hydroxylalkyl, aminylalkyl, alkylaminylalkyl, cyanoalkyl, carboxyalkyl, aminylcarbonylalkyl or aminylcarbonyl;
• R4a and R4b are, at each occurrence, independently H, —OH, —NH2, —CO2H, halo, cyano, C1-C6 alkyl, C2-C6 alkynyl, hydroxylalkyl, aminylalkyl, alkylaminylalkyl, cyanoalkyl, carboxyalkyl, aminocarbonylalkyl or aminocarbonyl;
• or one R4a and one R4b join to form a carbocyclic or heterocyclic ring, and each remaining R4a and R4b are, at each occurrence, independently H, —OH, —NH2, —CO2H, halo, cyano, C1-C6 alkyl, C2-C6 alkynyl, hydroxylalkyl, aminylalkyl, alkylaminylalkyl, cyanoalkyl, carboxyalkyl, aminocarbonylalkyl or aminocarbonyl;
• or one R4b joins with one R3b to form a carbocyclic or heterocyclic ring, and each R4a and each remaining R4b are, at each occurrence, independently H, —OH, —NH2, —CO2H, halo, cyano, C1-C6 alkyl, C2-C6 alkynyl, hydroxylalkyl, aminylalkyl, alkylaminylalkyl, cyanoalkyl, carboxyalkyl, aminylcarbonylalkyl or aminylcarbonyl;
• L1 is a bond or alkylene;
• L2 is a bond or a one, two or three atom linker, wherein the atoms are selected from nitrogen and carbon;
• m1 and m2 are each 2;
• m3 and m4 are each 1;
• represents a double or triple bond;
• Q is —C(═O)−, —C(═NR7)—, —NR8C(═O)—, —S(═O)2— or —NR8S(=O)2—;
• R7 is H, —OH, —CN or C1-C6 alkyl;
• R8 is H, C1-C6 alkyl or hydroxylalkyl;
• when is a double bond then R9 and R10 are each independently H, cyano, carboxyl, C1-C6 alkyl, alkoxycarbonyl, aminylalkyl, alkylaminylalkyl, heteroaryl or hydroxylalkyl;
• and
• when is a triple bond then R9 is absent and R10 is H, C1-C6 alkyl, aminylalkyl, alkylaminylalkyl or hydroxylalkyl.