Crystal form of deuterated AZD9291, preparation method therefor, and use thereof
AssigneeTyk Medicines, Inc.
InventorsYusheng Wu, Yang Geng, Apeng Liang, Chengshan Niu
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Abstract
A crystal form of a deuterated AZD9291 has an X-ray powder diffraction measured using Cu-Kα rays with diffraction peaks at 7.1±0.2, 8.5±0.2, 9.4±0.2, 10.3±0.2, 15.1±0.2, 16.3±0.2, 18.7±0.2, 22.0±0.2, 25.6±0.2, and 26.0±0.2. The crystal form of the deuterated AZD9291 is used in the preparation of medicaments for the treatment of cancer. The crystal form of the deuterated AZD9291 provided by the present invention has stable physical and chemical properties and good metabolic stability, and blood concentrations in vivo and concentrations in the brain thereof are significantly improved, achieving an improved therapeutic effect.
Claims9
A crystal form of deuterated AZD9291, characterized in that the structural formula is as shown in formula (I) or formula (II):
- the X-ray powder diffraction of the crystal form obtained by Cu-Kα ray measurement has diffraction peaks at a 2θ angle (unit:
- °) of:
- 7.1±0.2, 8.5±0.2, 9.4±0.2, 10.3±0.2, 15.1±0.2, 16.3±0.2, 18.7±0.2, 22.0±0.2, 25.6±0.2, and 26.0±0.2.
A crystal form of deuterated AZD9291, characterized in that the structural formula is as shown in formula (I) or formula (II):
- the X-ray powder diffraction of the crystal form obtained by Cu-Kα ray measurement has diffraction peaks at an 2θ angle (unit:
- °) of:
- 7.1±0.2, 8.5±0.2, 9.4±0.2, 10.3±0.2, 15.1±0.2, 16.3±0.2, 17.0±0.2, 17.3±0.2, 17.7±0.2, 18.7±0.2, 19.4±0.2, 19.7±0.2, 20.2±0.2, 20.7±0.2, 21.6±0.2, 22.0±0.2, 22.8±0.2, 23.5±0.2, 24.2±0.2, 24.8±0.2, 25.6±0.2, and 26.0±0.2.
A crystal form of deuterated AZD9291, characterized in that the structural formula is as shown in formula (I) or formula (II):
- the X-ray powder diffraction obtained of the crystal form by Cu-Kα ray measurement has diffraction peaks at an 2θ angle (unit:
- °) of:
- 7.1±0.2, 8.5±0.2, 9.4±0.2, 10.3±0.2, 12.6±0.2, 14.4±0.2, 15.1±0.2, 15.6±0.2, 16.3±0.2, 17.0±0.2, 17.3±0.2, 17.7±0.2, 18.2±0.2, 18.7±0.2, 19.4±0.2, 19.7±0.2, 20.2±0.2, 20.7±0.2, 21.6±0.2, 22.0±0.2, 22.8±0.2, 23.5±0.2, 24.2±0.2, 24.8±0.2, 25.6±0.2, 26.0±0.2, 26.9±0.2, 27.7±0.2, 28.2±0.2, 29.5±0.2, 30.7±0.2, 31.7±0.2, 32.5±0.2, 33.1±0.2, 33.8±0.2, 34.6±0.2, 34.9±0.2, 35.6±0.2, 37.9±0.2, and 38.7±0.2.
Dependencies are inferred from the claim text.