Cannabinergic compounds and uses thereof
AssigneeNortheastern University
InventorsAlexandros Makriyannis, Ganeshsingh A. Thakur, Rishi Sharma
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Abstract
Disclosed are compounds and compositions that modulate cannabinoid receptors, methods of modulating cannabinoid receptors, and methods of treating various disorders related to the modulation of cannabinoid receptors. This disclosure is directed to methods of treating cannabinoid dependence, neuropathy, inflammation, glaucoma, a neurodegenerative disorder, a motor function disorder, a gastrointestinal disorder, hypothermia, emesis, loss of appetite, or anorexia associated with AIDS.
Claims8
A compound of Formula I(c):
- or a pharmaceutically acceptable salt thereof, wherein X, R1, R2 and R3 are as follows:
- X
- R1
- R2
- R3
- C(O)
- CH3
- CH3
- CO2-n-butyl
- CH3
- CH3
- CO2-n-butyl
- CH3
- CH3
- CO2-n-butyl or
- CH3
- CH3
- CO2-n-butyl.
A method of treating hypothermia in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula I(c):
- or a pharmaceutically acceptable salt thereof, wherein X, R1, R2 and R3 are as follows:
- X
- R1
- R2
- R3
- CH3
- CH3
- CO2-n-butyl or
- CH3
- CH3
- CO2-n-butyl.
A method of treating neuropathic pain in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula I(c):
- or a pharmaceutically acceptable salt thereof, wherein X, R1, R2 and R3 are as follows:
- X
- R1
- R2
- R3
- C(O)
- CH3
- CH3
- CO2-n-butyl, or
- CH3
- CH3
- CO2-n-butyl.
Dependencies are inferred from the claim text.