Bicyclic heteroaryl derivatives and preparation and uses thereof
AssigneeXw Laboratories Inc.
InventorsJia-Ning Xiang, Xuesong Xu, Wei Zhou
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Abstract
The present invention relates compounds of Formula (A), as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses as modulators of dysfunctional glutamate transmission. The present invention also relates to uses of the compounds or pharmaceutical compositions in treating or preventing certain neurological and psychiatric disorders and diseases as well as cancer in humans.
Claims30
A method of suppressing, ameliorating, or relieving a symptom of epilepsy in a patient comprising administering to a patient in need thereof a therapeutically effective amount of a compound selected from:
- 6-(pentafluoro-λ6-sulfaneyl)benzo[d]thiazol-2-amine (I):
- 6-(pentafluoro-λ6-sulfaneyl)benzo[d][1,3]selenazol-2-amine (V):
- 6-(trifluoromethyl)benzo[d][1,3]selenazol-2-amine (VI):
- 6-((trifluoromethyl)thio)benzo[d][1,3]selenazol-2-amine (IX):
- or a pharmaceutically acceptable salt of any of the foregoing.
A method of treating chronic neuropathic pain in a patient comprising administering to a patient in need thereof a therapeutically effective amount of a compound selected from:
- 6-(pentafluoro-λ6-sulfaneyl)benzo[d]thiazol-2-amine (I):
- 6-(pentafluoro-λ6-sulfaneyl)benzo[d][1,3]selenazol-2-amine (V):
- 6-(trifluoromethyl)benzo[d][1,3]selenazol-2-amine (VI):
- 6-((trifluoromethyl)thio)benzo[d][1,3]selenazol-2-amine (IX):
- or a pharmaceutically acceptable salt of any of the foregoing.
A method of suppressing, ameliorating, or relieving a symptom of amyotrophic lateral sclerosis in a patient comprising administering to a patient in need thereof a therapeutically effective amount of a compound selected from:
- 6-(pentafluoro-λ6-sulfaneyl)benzo[d]thiazol-2-amine (I):
- 6-(pentafluoro-λ6-sulfaneyl)benzo[d][1,3]selenazol-2-amine (V):
- 6-(trifluoromethyl)benzo[d][1,3]selenazol-2-amine (VI):
- 6-((trifluoromethyl)thio)benzo[d][1,3]selenazol-2-amine (IX):
- or a pharmaceutically acceptable salt of any of the foregoing.
Dependencies are inferred from the claim text.