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US 10,882,831 B2Granted
Compositions useful in therapy of autophagy-related pathologies, and methods of making and using the same
AssigneesThe University of Toledo, Washington State University
InventorsKenneth Hensley, Travis Denton
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Abstract
Lanthionine ketimine phosphonate (LK-P), lanthionine ketimine ester phosphonate (LKE-P), other lanthionine ketimine, lanthionine ketimine phosphonate, and lanthionine ketimine ester derivatives, and methods of making and using the same, are described.
Claims29
A compound comprising Formula E:
- wherein:
- R1 is a substituted or unsubstituted alkyl, aryl, alkoxy, ester, alkenylamino, alkynylamino, aryloxy, aralkoxy, acyloxy, alkylamino, arylamino, aralkylamino, or amido group;
- R2 is hydrogen or substituted or unsubstituted alkyl, alkoxy, ester, alkenylamino, alkynylamino, aryloxy, aralkoxy, acyloxy, alkylamino, arylamino, aralkylamino, or amido;
- and
- R3 is hydrogen or a substituted or unsubstituted alkyl, alkoxy, ester, alkenylamino, alkynylamino, aryloxy, aralkoxy, acyloxy, alkylamino, arylamino, aralkylamino, or amido;
- and salts, stereoisomers, racemates, hydrates, solvates, polymorphs, and alkene reduction products thereof.
3 more elements
A compound comprising 2-isopropyl-AECK-P:
- and salts, stereoisomers, racemates, hydrates, solvates, polymorphs, and alkene reduction products thereof.
Dependencies are inferred from the claim text.