Quinolinone or quinazolinone comprising antibiofilm compositions, compounds and methods and uses relating thereto
AssigneeUniversity College Cork, National University of Ireland
InventorsFergal O'Gara, Jerry F. Reen, Gerard McGlacken
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Abstract
An antibiofilm composition comprising a compound of formula (A1), (A2) or (A3): wherein each of R1, R2, R3, R4, R5, R6 and R7 is independently selected from hydrogen, alkyl, alkenyl, aryl, halo, alkoxy, hydroxyl, amino, nitro, sulfoxy, thiol, carboxy, alkyl carboxy and amido; and X may be O or S, wherein the composition does not comprise a compound of formula (B1) or (B2):
Claims13
A method of combating a biofilm at a locus, the method comprising contacting the locus with a composition comprising a compound of formula:
A method of combating a fungal biofilm at a locus, the method comprising contacting the locus with a composition comprising a compound of formula (A1), (A2), or (A3):
- wherein each of R1, R2, R3, R5, R4, R6, and R7 is independently selected from hydrogen, alkyl, alkenyl, aryl, halo, alkoxy, hydroxyl, amino, nitro, sulfoxy, thiol, carboxy, alkyl carboxy, and amido.
A method of combating a biofilm at a locus, the method comprising contacting the locus with a composition comprising a compound of formula (A2):
- wherein R1 is hydrogen or methyl;
- R2 is hydrogen, C1 to C8 alkyl, halo or alkoxy;
- R3 is hydrogen, alkyl or alkoxy;
- R4 is hydrogen or halo;
- R6 is alkyl;
- and R7 is hydrogen or amino.
Dependencies are inferred from the claim text.