Non-solvated crystal, preparation method and application thereof
AssigneeShenzhen Chipscreen Biosciences Co., Ltd.
InventorsXianping Lu, Zhibin Li
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Abstract
The invention relates to non-solvated crystals A, B and C of N-(2-aminophenyl)-6-(7-methoxyquinoline-4-oxy)-1-naphthamide and preparation methods thereof. The invention also relates to pharmaceutical compositions containing the crystals, and a use of the crystals in preparation of a medicament for the treatment of a disease associated with abnormal protein kinase activity or abnormal histone deacetylase activity.
Claims16
A non-solvated crystal of N-(2-aminophenyl)-6-(7-methoxyquinoline-4-oxo)-1-naphthaleneformamide, wherein said non-solvated crystal is selected from non-solvated crystal A, non-solvated crystal B, and non-solvated crystal C, wherein
- the X-ray powder diffraction pattern of said non-solvated crystal A has characteristic peaks at reflection angles 2θ of 6.88°, 9.26°, 12.74°, 13.82°, 18.58°, 20.86° and 25.72°;
- the X-ray powder diffraction pattern of said non-solvated crystal B has characteristic peaks at reflection angles 2θ of 4.88°, 9.68°, 12.74°, 14.52°, 17.72°, 24.30° and 25.26°;
- and
- the X-ray powder diffraction pattern of said non-solvated crystal C has characteristic peaks at reflection angles 2θ of 4.84°, 9.68°, 12.92°, 14.60°, 16.46°, 17.44°, 22.00° and 25.28°.
Dependencies are inferred from the claim text.