Acetylsalicylic acid derivative crystal, its preparation method and use
AssigneeZhejiang Yuejia Pharmaceuticals Co., Ltd
InventorJing Zhang
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Abstract
A disclosed are an acetylsalicylic acid derivative, i.e. a 2-(diethylamino)ethyl 2-acetoxy-benzoate hydrochloride crystal, and a preparation method and use thereof. The X-ray powder diffraction (XRPD) pattern of the crystal has characteristic peaks at the following 2θ angle: 11.0°±0.2°, 20.6°±0.2°, 25.1°±0.2°, 8.2°±0.2°, 16.5°±0.2°, 13.4°±0.2°, 25.4°±0.2°.
Claims11
A method for treating indication which can be treated by acetylsalicylic acid, the indication being selected from pain, fevers, cardiovascular and cerebrovascular diseases, and inflammation, the method comprising administering to human in need thereof a therapeutically effective amount of a compound of 2-(diethylamino)ethyl 2-acetoxybenzoate hydrochloride crystal having a chemical structure as represented by formula I, wherein the X-ray powder diffraction (XRPD) pattern of the crystal having characteristic peaks at the following 2θ angles:
- 11.0°±0.2°, 20.6°±0.2°, 25.1°±0.2°, 8.2°±0.2°, 16.5°±0.2°, 13.4°±0.2°, 25.4°±0.2°;
A method for preparing the 2-(diethylamino)ethyl 2-acetoxybenzoate hydrochloride crystal, wherein the method comprises the steps of:
- (1) mixing a crude 2-(diethylamino)ethyl 2-acetoxybenzoate hydrochloride raw material with anhydrous acetonitrile, and completely dissolving the raw materials to obtain a solution where the final mass-volume ratio of the crude 2-(diethylamino)ethyl 2-acetoxybenzoate hydrochloride raw material to the anhydrous acetonitrile is 1:
- 4-1:10 w/v;
- and
- (2) cooling the solution to 0-30° C. to precipitate the 2-(diethylamino) ethyl 2-acetoxybenzoate hydrochloride crystal having a chemical structure as represented by formula I, wherein the X-ray powder diffraction (XRPD) pattern of the crystal having characteristic peaks at the following 2θ angles:
- 11.0°±0.2°, 20.6°±0.2°, 25.1°±0.2°, 8.2°±0.2°, 16.5°±0.2°, 13.4°±0.2°, 25.4°±0.2°.
Dependencies are inferred from the claim text.