Method for the synthesis of ferric oraganic compounds
AssigneeBiophore India Pharmaceuticals PVT. Ltd.
InventorsManik Reddy Pullagurla, Mecheril Valsan Nanda Kumar, Jagadeesh Babu Rangisetty, Rajesh Bhudeti, Radha Nagarapu
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Abstract
The present invention relates to an improved method for the synthesis of Ferric Citrate and also to provide an amorphous form of Ferric Citrate having an active surface area less than 14 sq.m/g.
Claims14
A process for preparing Ferric Citrate having (BET) surface area less than 14 m2/g and with intrinsic dissolution rate of about 0.1-1.5 mg/cm2/min, the process comprising:
- a) adding alkali metal carbonate to an aqueous solution of ferric chloride in the range of 25-30° C.;
- b) isolating solid ferric hydroxide at a pH in the range of 6.8 to 8.5;
- c) adding ferric hydroxide to an aqueous solution of citric acid monohydrate and heating in the range of 80 to 120° C.;
- and
- d) reducing the volume of water from 60% to 30% followed by precipitation of Ferric Citrate by one of adding it to water miscible organic solvent in the range of 25-30° C. and adding water miscible organic solvent to it.
A process for preparing Ferric Citrate having (BET) active surface area of less than 14 m2/g, comprising:
- a) treating 1 volume of 10% of water in water miscible organic solvent to Ferric Citrate having (BET) surface area greater than 14 m2/g;
- and
- b) optionally blending the sample for uniformity.
A process for reducing (BET) active surface area of Ferric Citrate to less than 14 m2/g, comprising:
- a) treating 1 volume of 10% of water in water miscible organic solvent to Ferric Citrate having (BET) surface area greater than 14 m2/g;
- and
- b) optionally blending the sample for uniformity.
Dependencies are inferred from the claim text.