US 10,882,008 B2Granted

Apparatus for processing biological sample

AssigneeTaigen Bioscience Corporation

InventorChi-Sheng Tai

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Abstract

An apparatus for processing biological sample is provided, which comprises a semi-permeable membrane column, an adaptor column and a vacuum manifold. The at least one semi-permeable membrane column is configured for accommodating biological sample therein and comprises a curved surface. The at least one adaptor column is configured for accommodating the semi-permeable membrane column therein and comprises a stopping element. The vacuum manifold is configured for creating a vacuum that facilitates flowing of the biological sample into the semi-permeable membrane column through a semi-permeable membrane therein. The stopping element abuts against the curved surface. By disposing the stopping element within the adaptor column, the present disclosure prevents the biological sample from suffering an unbalance pressure to splash upwardly outside the semi-permeable membrane column thereby causing a possibility of decreasing the testing efficiency, when the semi-permeable membrane column is removed out of the adaptor column.

Claims8

Dependent claims

An apparatus for processing a biological sample, comprising:

at least one semi-permeable membrane column wherein a first receiving space is defined in an inner portion of the semi-permeable membrane column, a bottom of the first receiving space comprises at least one semi-permeable membrane, a top portion of the semi-permeable membrane column comprises a first opening and a first protrusion protruding radially outward, and a bottom portion of the semi-permeable membrane column comprises a first outlet and a curved surface;
at least one adaptor column wherein a second receiving space is defined in an inner portion of the adaptor column, a top portion of the adaptor column comprises a second opening and a second protrusion protruding radially outward, and a bottom portion of the adaptor column comprises a second outlet and a stopping element, a diameter of the second receiving space is slightly larger than an outer diameter of the first receiving space, and the stopping element is disposed inside the at least one adaptor column to cause the curved surface of the at least one semi-permeable membrane to lean against the stopping element inside the at least one adaptor column in a loose-fit connection;
and
a vacuum manifold, comprising a base and a lid covering the base, wherein a storing space is defined inside the base, the lid is formed with at least one slot and a bottom of the at least one slot comprises a through hole for connecting with the storing space of the base, and a diameter of the slot is slightly larger than an outer diameter of the adapter column, and the stopping element is contactless with a distal end of the first outlet
wherein the curved surface is a conic surface which has a minimum outermost diameter equal to an outer diameter of the first outlet but smaller than an inner diameter of the stopping element, and has a maximum outermost diameter equal to the outer diameter of the at least one semi-permeable membrane column but larger than the inner diameter of the stopping element.

2 more elements

An apparatus for processing a biological sample, comprising:

at least one semi-permeable membrane column wherein a first receiving space is defined in an inner portion of the semi-permeable membrane column, the first receiving space is used for receiving a biological sample, a bottom of the first receiving space comprises at least one semi-permeable membrane, and a bottom portion of the semi-permeable membrane column comprises a first outlet and an outer surface;
at least one adaptor column wherein a second receiving space is defined in an inner portion of the adaptor column, and a bottom portion of the adaptor column comprises a second outlet and a stopping element, a diameter of the second receiving space is slightly larger than an outer diameter of the first receiving space, the stopping element is disposed inside the at least one adaptor column to cause the outer surface of the at least one semi-permeable membrane to lean against the stopping element inside the at least one adaptor column in a loose-fit connection;
and
a vacuum manifold, for receiving the at least one semi-permeable membrane column and the at least one adaptor column therein, and for generating a pressure to make the biological sample pass through the at least one semi-permeable membrane, and the stopping element is contactless with a distal end of the first outlet
wherein the outer surface has a minimum outermost diameter equal to an outer diameter of the first outlet but smaller than an inner diameter of the stopping element, and has a maximum outermost diameter equal to the outer diameter of the at least one semi-permeable membrane column but larger than the inner diameter of the stopping element.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application: 15/887,917Filed 2 Feb 2018
Priority: TW 106130509 A6 Sep 2017
Published: US 2019/0070563 A17 Mar 2019
Granted: 5 Jan 2021
Term ends: Not estimatedThe source records don’t support an estimate.

Classification18 codes

B01D 63/062
Tubular membrane modules: with membranes on a surface of a support tube
B01L 3/50255
For parallel transport of multiple samples: multi-well filtration
G01N 1/34
Preparing specimens for investigation including physical details of chemical methods covered elsewhere, e.g. G01N33/50, C12Q: purifying; Cleaning
G01N 1/4005
Concentrating samples: by transferring a selected component through a membrane