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US 10,881,985 B1Granted
System with reusable column with resin packing and unpacking procedures and sample analysis
AssigneeElemental Scientific, Inc.
InventorMichael Paul Field
Life of this patent
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Abstract
Systems and methods for automatically packing resin into and unpacking resin from a reusable separation column for sample analysis are described. A method embodiment includes, but is not limited to, introducing a slurry of resin to a reusable sample separation column to pack the reusable column with resin; introducing a sample solution to the reusable sample separation column; and unpacking the resin from the reusable sample separation column with a flow of liquid unpacking reagent and gaseous material.
Claims19
A method comprising:
- introducing, via pump operation, a first slurry of resin to a first end of a first reusable sample separation column coupled with a valve system to pack resin from the first slurry of resin into the first reusable sample separation column when the valve system is in a first resin packing configuration;
- introducing, via pump operation, a second slurry of resin to a first end of a second reusable sample separation column coupled with the valve system to pack resin from the second slurry of resin into the second reusable sample separation column when the valve system is in a second resin packing configuration;
- introducing, via pump operation, a sample solution to the first reusable sample separation column and the second reusable sample separation column when the valve system is in a sample load configuration;
- mixing a gas and an unpacking reagent in the valve system;
- introducing, via pump operation, the mixed gas and unpacking reagent to a second end of the first reusable sample separation column to unpack resin from the first reusable sample separation column and transfer the resin out of the first end of the first reusable sample separation column, wherein the second end of the first reusable sample separation column is distal the first end of the first reusable sample separation column;
- and
- introducing, via pump operation, the mixed gas and unpacking reagent to a second end of the second reusable sample separation column to unpack resin from the second reusable sample separation column and transfer the resin out of the first end of the second reusable sample separation column, wherein the second end of the second reusable sample separation column is distal the first end of the second reusable sample separation column.
4 more elements
A method comprising:
- introducing, via pump operation, a slurry of resin to a first end of a reusable sample separation column coupled with a valve system to pack resin from the slurry of resin into the reusable sample separation column when the valve system is in a resin packing configuration;
- introducing, via pump operation, a sample solution to the reusable sample separation column when the valve system is in a sample load configuration;
- mixing a gas and an unpacking reagent in the valve system;
- and
- introducing, via pump operation, the mixed gas and unpacking reagent to a second end of the reusable sample separation column to unpack resin from the reusable sample separation column and transfer the resin out of the first end of the reusable sample separation column, wherein the second end of the reusable sample separation column is distal the first end of the reusable sample separation column.
2 more elements
Dependencies are inferred from the claim text.