Transcutaneous neuromodulation system and methods of using same
AssigneeThe Regents of the University of California, a California corporation
InventorsVictor Reggie Edgerton, Yury P. Gerasimenko, Nicholas A. Terrafranca, Parag Gad
Life of this patent
Estimating the term…
Abstract
Neuromodulation systems are described comprising a signal generator and at least one electrode. The at least one electrode can be configured to deliver a stimulation to a mammal, wherein the stimulation includes a biphasic signal and an overlapping high frequency pulse thereby inducing voluntary movement in the individual. Methods of administering the stimulation are also described.
Claims20
A neuromodulation system comprising:
- a processor;
- a signal generator;
- and
- at least one electrode,
- wherein the processor, in cooperation with the signal generator and the at least one electrode are configured to deliver a transcutaneous stimulation to a mammal, the transcutaneous stimulation for inducing voluntary movement in the mammal and including:
- during a first time period, a transcutaneous electrical spinal cord stimulation (“tESCS”) applied to the mammal during physical conditioning of the mammal,
- during a second time period after the first time period, the tESCS applied to the mammal during reduced or no physical conditioning of the mammal, and
- during a third time period after the second time period, the tESCS applied to the mammal during the physical conditioning of the mammal in conjunction with pharmacological enabling motor control (“fEmc”), and
- wherein the tESCS applied during the first time period and the second time period is used to establish a functional baseline of the mammal.
A method of inducing a voluntary movement in a mammal with a spinal injury, the method comprising:
- applying a stimulation to the mammal using a transcutaneous neuromodulation system for inducing the voluntary movement,
- wherein the stimulation is applied by:
- during a first time period, providing a transcutaneous electrical spinal cord stimulation (“tESCS”) to the mammal during physical conditioning of the mammal, and
- during a second time period after the first time period, providing the tESCS to the mammal during the physical conditioning of the mammal in conjunction with pharmacological enabling motor control (“fEmc”), and
- wherein the tESCS applied during the first time period is used to establish a functional baseline of the mammal.
Dependencies are inferred from the claim text.