Systems for producing an aerosol and related methods of use

A system comprising:

• a nebulizing body including at least one electro-mechanical nebulizing element;
• and a replaceable cartridge including one or more fluid reservoirs and a valve in fluid communication with the one or more fluid reservoirs, wherein the nebulizing body is configured to releaseably receive the replaceable cartridge without engaging with the replaceable cartridge, and wherein the nebulizing body includes a switch configured to selectively engage the replaceable cartridge when the replaceable cartridge is releaseably received by the nebulizing body, thereby placing the valve in an open state, wherein the nebulizing body and the replaceable cartridge are cooperatively configured such that the replaceable cartridge can be releaseably received by and engaged with the nebulizing body after having been previously releaseably received by and engaged with the nebulizing body.