Delivery device including reactive material for programmable discrete delivery of a substance

A digital biomedical device comprising:

• a substrate forming a cavity;
• a seal formed on the substrate and encircling the cavity;
• a lid coupled to the substrate by the seal, the lid comprising at least one via;
• a reactive metal structure comprising a plurality of metal layers, wherein the reactive metal structure is disposed in the at least one via of the lid;
• a metal trace configured to initiate a self-propagating reaction between the plurality of metal layers of the reactive metal structure and release contents of the cavity through the at least one via;
• and
• a power supply configured to apply an electric current to the metal trace.