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US 10,881,748 B2Granted
Nitroxide containing amyloid binding agents for imaging and therapeutic uses
AssigneeThe Regents of the University of California
InventorsJohn Voss, Ruiwu Liu
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Abstract
The present invention provides methods of using nitroxide spin-labeled amyloid beta-binding compounds to image amyloid. The present invention also provides nitroxide spin-labeled amyloid beta-binding compounds.
Claims8
A method of imaging amyloid, comprising:
- administering to a subject an effective amount of a compound, wherein the compound is selected from the group consisting of:
- wherein:
- R1 is selected from the group consisting of:
- R2 is selected from the group consisting of OH, OCH3, OCH2CH3, OCH2CH2F, CH3, and (OCH2CH2)3F;
- and
- Ra and Rb are each independently H or C1-4 alkyl and detecting the compound bound to the amyloid, thereby imaging the amyloid.
3 more elements
A diagnostic composition for imaging amyloid, comprising a compound, wherein the compound is selected from the group consisting of:
- wherein:
- R1 is selected from the group consisting of:
- R2 is selected from the group consisting of OH, OCH3, OCH2CH3, OCH2CH2F, CH3, and (OCH2CH2)3F;
- and
- Ra and Rb are each independently H or C1-4 alkyl.
2 more elements
A method of treating a disorder, the method comprising administering to a subject in need thereof, a therapeutically effective amount of a compound, wherein the compound is selected from the group consisting of:
- wherein:
- R1 is selected from the group consisting of:
- R2 is selected from the group consisting of OH, OCH3, OCH2CH3, OCH2CH2F, CH3, and (OCH2CH2)3F;
- and
- Ra and Rb are each independently H or C1-4 alkyl;
- and
- wherein the disorder is selected from the group consisting of Alzheimer's disease, diabetes Parkinson's disease, spongiform encephalopathy, Huntington's disease, thyroid carcinoma, atrial amyloidosis, atherosclerosis, arthritis, prolactinomas, polyneuropathy, corneal dystrophy, and cerebral amyloid angiopathy.
4 more elements
Dependencies are inferred from the claim text.