Glycan-dependent immunotherapeutic molecules

A composition comprising at least one selected from the group consisting of:

• a) a peptide comprising a tumor-associated carbohydrate antigen (TACA)-binding domain derived from a lectin, and an immune cell recognition domain that specifically binds to a receptor on an immune effector cell;
• and
• b) an isolated nucleic acid molecule encoding a peptide, wherein the peptide comprises a TACA-binding domain derived from a lectin, and an immune cell recognition domain that specifically binds to a receptor on an immune effector cell,
• wherein the TACA-binding domain specifically binds to a TACA of a tumor cell,
• wherein:
• the lectin is selected from the group consisting of a galectin, a siglec, a selectin;
• a C-type lectin;
• CD301, L-PHA (Phaseolus vulgaris leukoagglutinin);
• E-PHA (Phaseolus vulgaris erythroagglutinen);
• tomato lectin (Lycopersicon esculentum lectin;
• LEA);
• peanut lectin (Arachis hypogaea Agglutinin;
• PNA);
• potato lectin (Solanum tuberosum lectin), pokeweed mitogen (Phytolacca American lectin), wheat germ agglutinin (Triticum Vulgaris lectin);
• Artocarpus polyphemus lectin (Jacalin letin);
• Vicia villosa Agglutinin (VVA);
• Helix pomatia Agglutinin (HPA);
• Wisteria floribunda Agglutinin (WFA);
• Sambucus nigra Agglutinin (SNA), BC2L-CNt (lectin from the gram negative bacteria Burkholderia cenocepacia), Maackia amurensis leukoagglutinin (MAL), Psathyrella velutina (PVL), Sclerotium rolfsii lectin (SRL), Eucheuma serra agglutinin (ESA), CLEC17A (Prolectin), Aleuria aurantia lectin, Sambucus sieboldiana lectin (SSA), Glechoma hederacea lectin (Gleheda), Morus nigra agglutinin (Morniga G), Salvia sclarea lectin, Salvia bogotensis lectin, Salvia horminum lectin, Clerodendrum trichotomum lectin, Moluccella laevis lectin, Griffonia simplicifolia (GsLA4), Psophocarpus tetragonolobus (acidic WBAI), Abrus precatorius lectin, Amaranthus caudatus lectin, Amaranthus leucocarpus lectin, Laelia autumnalis lectin, Artocarpus integrifolia lectin, Maclura pomifera lectin, Artocarpus lakoocha lectin, Dolichos biflorus agglutinin, Dolichos biflorus lectin, Glycine max lectin, and Agaricus bisporus lectin;
• wherein the immune effector cell is selected from the group consisting of T cells, natural killer (NK) cells, natural killer T (NKT) cells, macrophages, monocytes, dendritic cells, and neutrophils.