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US 10,881,738 B2Granted
Oligomer-beta blocker conjugates
AssigneeNektar Therapeutics
InventorsJennifer Riggs-Sauthier, Franco J. Duarte, Aaron S. Hammons
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Abstract
The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a different biological membrane crossing rate as compared to the biological membrane crossing rate of the small molecule drug not attached to the water-soluble oligomer.
Claims10
A method of treating hypertension, cardiac arrhythmia, migraines, congestive heart failure, angina, anxiety, or depression, comprising:
- administering an effective amount of a compound of the following formula to a patient in need thereof:
- wherein:
- R1 is lower alkyl;
- R2 is hydrogen;
- R3 is H;
- R4 is H;
- R5 is H;
- R6 is H;
- R7 is H;
- Ar is
- and
- where
- optionally bears one or more halo, alkyl, alkoxy, or acyl substituents.
10 more elements
Dependencies are inferred from the claim text.