Biophotonic compositions comprising a chromophore and a gelling agent for treating wounds
AssigneeKlox Technologies Inc.
InventorsNikolaos Loupis, Remigio Piergallini, Shipra Rastogi
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Abstract
The present disclosure provides biophotonic compositions, kits and their uses. In particular, the biophotonic compositions of the present disclosure are substantially resistant to leaching such that low amounts of chromophores present in the biophotonic composition leach out of the composition. The biophotonic compositions and their uses are useful for promoting repair of non-healing wounds.
Claims21
A method for stimulating repair of a Grade II chronic wound, or of a Grade III chronic wound, or both, to generate a closed wound without a hollow under a surface of the closed wound, comprising:
- applying topically a biophotonic composition to the Grade II chronic wound, or to the Grade III chronic wound, or to both;
- wherein the biophotonic composition comprises:
- at least a first chromophore;
- and
- a gelling agent present in an amount sufficient to gel the composition and render the biophotonic composition substantially resistant to leaching such that less than 15% by weight of the total chromophore amount leaches out of the biophotonic composition in use, and such that the biophotonic composition has a viscosity of between about 10,000 cP and about 50,000 cP;
- and
- illuminating the applied biophotonic composition with a light source emitting a light having a wavelength that overlaps with an absorption spectrum of the first chromophore and a power density of between about 50-150 mW/cm2 at a distance of about 5 cm from the light source.
A method for stimulating collagen formation at a Grade II chronic wound, a Grade III chronic wound, or at both to generate a closed wound without a hollow under a surface of the closed wound comprising:
- applying topically a biophotonic composition to the Grade II chronic wound, the Grade III chronic wound, or to both;
- wherein the biophotonic composition comprises:
- at least a first chromophore;
- and
- a gelling agent present in an amount sufficient to gel the composition and render the biophotonic composition substantially resistant to leaching such that less than 15% by weight of the total chromophore amount leaches out of the biophotonic composition in use, and such that the biophotonic composition has a viscosity of between about 10,000 cP and about 50,000 cP;
- and
- illuminating the applied biophotonic composition with a light source emitting a light having a wavelength that overlaps with an absorption spectrum of the first chromophore and a power density of between about 50-150 mW/cm2 at a distance of about 5 cm from the light source.
A method for stimulating repair of a Grade II chronic wound, a Grade III chronic wound, or both, to generate a closed wound without a hollow under a surface of the closed wound, comprising:
- topically applying to the Grade II chronic wound, the Grade III chronic wound, or to both a biophotonic composition followed by illumination of the biophotonic composition applied at the wound base with an actinic light source emitting a light having a power density of between about 50-150 mW/cm2 at a distance of about 5 cm from the light source, wherein the biophotonic composition comprises:
- at least a first chromophore;
- and
- a gelling agent present in an amount sufficient to gel the composition and render the biophotonic composition substantially resistant to leaching such that less than 15% by weight of the total chromophore amount leaches out of the biophotonic composition in use, and such that the biophotonic composition has a viscosity of between about 10,000 cP and about 50,000 cP;
- and
- wherein the method comprises the following schedule:
- (a) a period of from 1 day to 24 weeks during which said biophotonic composition is topically applied to the Grade II chronic wound, the Grade III chronic wound, or to both, followed by
- (b) a rest period of from 3 days to 30 days;
- and
- (c) repeating at least (a) until wound closure.
Dependencies are inferred from the claim text.