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US 10,881,733 B2Granted
Benzamide and active compound compositions and methods of use
AssigneeTranslational Drug Development, LLC
InventorsTong Wang, Stephen Gately, Paul Gonzales
Life of this patent
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Abstract
The present invention describes compositions, including pharmaceutical compositions, comprising a PD-1 axis binding antagonist, a CTLA4 antagonist, or a DNA demethylating agent and a benzamide compound and methods for use thereof, for example in the treatment of cancer. In some implementations, the methods for use including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer.
Claims17
A composition comprising:
- An antibody against PD-1, wherein the antibody against PD-1 is a PD-1 axis binding antagonist;
- and
- A compound selected from the group consisting of 4-(1-(cyclohexylmethyl)-1H-benzo[d]imidazole-2-ylamino)-N-hydroxybenzamide, 4-(1-cyclohexyl-1H-benzo[d]imidazole-2-ylamino)-N-hydroxybenzamide and 4-(1-cycloheptyl-1H-benzo[d]imidazole-2-ylamino)-N-hydroxybenzamide.
Dependencies are inferred from the claim text.