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US 10,881,731 B2Granted
Methods for inducing an immune response
AssigneeGlaxosmithkline Biologicals SA
InventorsMargherita Coccia, Arnauld Michel Didierlaurent
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Abstract
The present invention relates to methods for inducing an immune response, in particular methods for adjuvanting the immune response to an antigen comprising the separate administration of a saponin and a TLR4 agonist.
Claims10
A method for adjuvanting the immune response of a subject to an antigen using 3-de-O-acylated monophosphoryl lipid A and QS21, said method comprising the steps:
- (i) administering to the subject the 3-de-O-acylated monophosphoryl lipid A;
- (ii) administering to the subject the QS21;
- (iii) administering to the subject the antigen;
- wherein the steps can be undertaken in any order, the 3-de-O-acylated monophosphoryl lipid A and the QS21 are administered separately, and antigen may optionally be co-formulated with the 3-de-O-acylated monophosphoryl lipid A, the QS21 or co-formulated with each of the 3-de-O-acylated monophosphoryl lipid A and QS21 and wherein the 3-de-O-acylated monophosphoryl lipid A, QS21 and antigen are all administered within 6 hours.
1 more element
Dependencies are inferred from the claim text.