Vaccine adjuvant compositions
AssigneeChildren's Medical Center Corporation
InventorsSimon D. Van Haren, Ofer Levy, David J. Dowling
Life of this patent
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Abstract
Embodiments described herein relate to combinatorial compositions and uses thereof, for example, as vaccine adjuvant compositions, for enhancing immune response, for inducing differentiation of nave T cells to differentiate into IFN-γ-producing T cells, and for preventing and treating infections. The combinatorial composition comprises TLR and CLR agonists. The combinatorial composition comprises at least one TLR4 agonist and at least one Dectin-1 agonist, wherein the at least TLR4 agonist is monophosphoryl lipid A (MPLA) or glycopyranosyl lipid A (GLA), or the combinatorial composition comprises at least one TLR7/8 agonist and at least one Mincle agonist.
Claims16
A synergistic composition comprising at least one TLR7/8 agonist, at least one Mincle agonist, and at least one antigen, and is formulated as a vaccine composition, wherein the composition activates newborn monocyte-derived dendritic cells (MoDCs) in an amount higher than a sum of activation of newborn MoDCs by the TLR7/8 agonist and the Mincle agonist used alone.
Dependencies are inferred from the claim text.