Method for inactivating viruses using electron beams
AssigneeFraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
InventorsSebastian Ulbert, Christiane Wetzel
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Abstract
The invention relates to a method for inactivating viruses, characterized in that an immunogenic composition or vaccine comprising at least one virus is irradiated with electron beams, said immunogenic composition or vaccine comprising at least one virus (i) being liquid, in particular being a suspension and (ii) comprising at least one viral immunogen, wherein the antigen structure is preferably substantially retained.
Claims21
A method for inactivating viruses, characterized in that an immunogenic composition or vaccine comprising at least one virus is irradiated with electron beams, said immunogenic composition or vaccine comprising at least one virus
- (i) being liquid, and
- (ii) comprising at least one viral immunogen,
- wherein said immunogenic composition or vaccine comprising at least one virus is irradiated with an electron beam dose in the range of between 15 and 110 kGy and the irradiation time is in the range of between 1 second and 100 seconds, and wherein the irradiation is carried out using a device for generating electron beams which is operated continuously.
A method for preparing a vaccine comprising at least one viral immunogen, characterized in that:
- (a) an immunogenic composition comprising at least one virus is irradiated with electron beams, said immunogenic composition comprising at least one virus (i) being liquid, and (ii) comprising at least one viral immunogen,
- wherein said immunogenic composition or vaccine comprising at least one virus is irradiated with an electron beam dose in the range of between 15 and 110 kGy and the irradiation time is in the range of between 1 second and 100 seconds, and wherein the irradiation is carried out using a device for generating electron beams which is operated continuously,
- (b1) one or more adjuvants are optionally added to the immunogenic composition comprising at least one virus, and/or
- (b2) one or more pharmaceutically acceptable excipients and/or auxiliaries are optionally added to the immunogenic composition comprising at least one virus, and/or
- (b3) one or more further immunogens are optionally added to the immunogenic composition comprising at least one virus,
- wherein the steps (a) to (b3) are carried out in any sequence.
Dependencies are inferred from the claim text.