Nanoparticles for immune stimulation
AssigneesBoard of Regents, The University of Texas System, Rensselaer Polytechnic Institute
InventorsElizabeth Leadbetter, Eyal Amiel, Emilie Vomhof-Dekrey, Robert Lindhardt, Amanda MacDonald, Jianjun Maio
Life of this patent
Estimating the term…
Abstract
The invention relates, in part, to nanoparticles, methods for preparing nanoparticles and methods of administering nanoparticles for immune stimulation. An immune-stimulating nanoparticle of the invention may include, at least in part, a polymer substrate comprising a biodegradable polymer and may include at least one antigen and/or at least one adjuvant.
Claims3
A method of producing a nanoparticle capable of eliciting a greater immunoglobulin M response as compared to an immunoglobulin G response, the method comprising,
- (a) preparing a polymer substrate comprising a polysaccharide antigen derived from Streptococcus pneumoniae intercalated with a biodegradable polymer;
- (b) selecting an adjuvant that in cooperation with the polysaccharide antigen is capable of eliciting an antibody response specific to the polysaccharide antigen in a subject, wherein the adjuvant is a natural or synthetic alpha-galactosylceramide compound;
- and
- (c) encapsulating the selected adjuvant with the polymer substrate to produce the nanoparticle capable of eliciting about 1000-fold greater immunoglobulin M response specific to the polysaccharide antigen as compared to an immunoglobulin G response specific to the polysaccharide antigen.
Dependencies are inferred from the claim text.