Bifunctional conjugate compositions and associated methods
AssigneeUniversity of Kansas
InventorsCory Berkland, Joshua Sestak, Teruna J. Siahaan
Life of this patent
Estimating the term…
Abstract
Bifunctional conjugate compositions are provided comprising a Signal-1 moiety bound to a first polymer carrier, wherein the combined size of the Signal-1 moiety and the first polymer carrier is about 1 nanometer to about 500 nanometers; and a Signal-2 moiety bound to a second polymer carrier, wherein the combined size of the Signal-2 moiety and the second polymer carrier is about 1 nanometer to about 500 nanometers. In some embodiments, the Signal-1 moiety and the Signal-2 moiety are bound to the same polymer carrier. Associated methods are also provided.
Claims25
A composition comprising:
- a first conjugate comprising Signal-1 peptides bound to a first polymer carrier, wherein the first polymer carrier is a glycosaminoglycan, wherein the molecular weight of the first conjugate is from about 5 kDa to about 100 kDa, and wherein the size of the first conjugate is about 1 nanometer to about 10 nanometers.
A method comprising administering to a subject in need thereof a therapeutically effective amount of composition comprising:
- a first conjugate comprising Signal-1 peptides bound to a first polymer carrier, wherein the combined size of the first conjugate is about 1 nanometer to about 10 nanometers;
- and
- a second conjugate comprising Signal-2 peptides hound to a second polymer carrier wherein the size of the second conjugate is about 1 nanometer to about 10 nanometers, wherein the first polymer carrier and the second polymer carrier are each a glycosaminoglycan, and wherein no Signal-2 peptides are associated with the first conjugate and no Signal-1 peptides are associated with the second conjugate.
A method comprising:
- providing a polymer carrier comprising at least one reactive amide or aminooxy group;
- providing a Signal-1 peptide comprising at least one reactive amide or aminooxy group or a Signal-2 peptide comprising at least one reactive amide and reacting the polymer carrier with the Signal-1 peptide or the Signal-2 peptide to form a conjugate via a A-oxime bond wherein the polymer carrier is a glycosaminoglycan.
Dependencies are inferred from the claim text.