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US 10,881,711 B2Granted
Anti-CSPG4 reagents and methods of treating cancer
AssigneeThe General Hospital Corporation
InventorsSoldano Ferrone, Xinhui Wang
Life of this patent
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Abstract
Embodiments of the present invention provide antibodies, antigen binding portions thereof, and other polypeptides (e.g., CARs), that specifically bind to CSPG4, an antigen expressed on cancer cells. Monoclonal antibodies, antibody-drug conjugates, and/or CAR-T-cells that specifically bind to CSPG4 positive cancer cells are also provided.
Claims15
An isolated antibody or antigen-binding portion thereof comprising the following heavy and light chain complimentarity determining regions (CDRs):
- a. a light chain CDR1 having the amino acid sequence of SEQ ID NO:
- 4;
- b. a light chain CDR2 having the amino acid sequence of SEQ ID NO:
- 5;
- c. a light chain CDR3 having the amino acid sequence of SEQ ID NO:
- 6;
- d. a heavy chain CDR1 having the amino acid sequence of SEQ ID NO:
- 1;
- e. a heavy chain CDR2 having the amino acid sequence of SEQ ID NO:
- 2;
- and
- f. a heavy chain CDR3 having the amino acid sequence of SEQ ID NO:
- 3.
10 more elements
Dependencies are inferred from the claim text.