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US 10,881,709 B2Granted
Immune system modulators and compositions
AssigneeCanimguide Therapeutics AB
InventorLeif Håkansson
Life of this patent
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Abstract
The present invention described herein relates to molecules and compositions that interact with molecules that suppress the immune system. More specifically, embodiments described herein concern the discovery, manufacture, and use of compositions that remove immunosuppression the immune system by binding to immunoregulatory peptides that interact with receptors on immune cells, compositions that can stimulate immune cells, and compositions that are cytotoxic to tumor cells.
Claims10
A method of inhibiting a metastatic cancer in a subject, the method comprising:
- selecting a subject that has a metastatic cancer having at least a first tumor and a second tumor;
- administering a composition comprising an isolated peptide comprising the amino acid sequence FFVKLS (SEQ ID NO:
- 62) systemically;
- wherein the isolated peptide comprises no more than 30 amino acid residues and binds to an albumin fragment comprising the sequence of P3028 (SEQ ID NO:
- 185);
- thereby inhibiting the metastatic cancer.
3 more elements
A composition comprising:
- an isolated peptide consisting of the amino acid sequence FFVKLS (SEQ ID NO:
- 62);
- and
- a support, in which the isolated peptide is immobilized on the support.
1 more element
Dependencies are inferred from the claim text.