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AssigneesThe Trustees of the University of Pennsylvania, Monell Chemical Senses Center, The United States Government as represented by the Department of Veterans Affairs
InventorsNoam A. Cohen, Robert J. Lee, Danielle R. Reed
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The invention provides methods and compositions for the diagnosis, prognosis and treatment of respiratory tract diseases. Specifically, the invention provides diagnosis, prognosis and treatment of respiratory infections using bitter and sweet taste signal transduction pathways. In one aspect, the invention relates to a method for treating a respiratory infection by administering a composition to the respiratory tract of a subject in an amount capable of activating bitter taste signaling and/or inhibiting sweet taste signaling. The composition comprises at least a bitter receptor agonist and, optionally, a pharmaceutically acceptable carrier for delivering the composition to the respiratory tract. In another aspect, the invention relates to a composition for treatment of a respiratory infection. Such composition comprises at least a bitter receptor agonist and, optionally, a pharmaceutically acceptable carrier for delivering the composition to the respiratory tract.
A method for treating an upper respiratory infection in the upper respiratory tract of a subject, the method comprising:
A method for treating an upper respiratory infection associated disease or disorder and for stimulating an innate antimicrobial response by stimulating NO production in the upper respiratory tract of a subject, the method comprising:
A method for treating an upper respiratory infection associated disease or disorder and for stimulating an innate antimicrobial response by stimulating nitric oxide (NO) production in the upper respiratory track of a subject having homozygous AVI/AVI allele, homozygous PAV/PAV allele or heterozygous PAV/AVI allele, the method comprising:
Dependencies are inferred from the claim text.