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US 10,881,693 B2Granted
Processes for making and using a mesenchymal stem cell derived secretome
AssigneeCombangio, Inc.
InventorSpencer Alford
Life of this patent
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Abstract
The present application provides methods and processes for making and using a mesenchymal stem cell secretome, as well as methods for treating ocular conditions and/disorders with the mesenchymal stem cell secretome described herein.
Claims24
A bone marrow-derived mesenchymal stem cell (MSC) secretome composition comprising:
- HGF;
- Pentraxin-3 (TSG-14);
- VEGF;
- TIMP-1;
- Serpin E1;
- <5 ng/mL IL-8, and a tonicity modifying agent.
3 more elements
A stable bone marrow-derived mesenchymal stem cell (MSC) secretome formulation comprising:
- i. 2 μg-20 μg of MSC secretome per mL;
- ii. 2 mg-3 mg monobasic sodium phosphate per mL;
- iii. 11 mg-12 mg dibasic sodium phosphate per mL;
- iv. 11.5 mg-13 mg mannitol per mL;
- v. 23 mg-24 mg trehalose dihydrate;
- vi. 0.5 mg-2 mg hypromellose per mL;
- and
- wherein the pH is about 4.7 to about 7.5.
5 more elements
A stable bone marrow-derived mesenchymal stem cell (MSC) secretome formulation comprising:
- i. 0.004%-0.08% w/w of MSC secretome;
- ii. 4%-5% w/w monobasic sodium phosphate;
- iii. 21.5%-23% w/w dibasic sodium phosphate;
- iv. 23%-25% w/w mannitol;
- v. 46%-48% w/w trehalose dehydrate;
- vi. 1%-3% w/w hypromellose;
- and
- wherein the pH is about 4.7 to about 7.5.
5 more elements
Dependencies are inferred from the claim text.