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US 10,881,682 B2Granted
Therapeutic compositions comprising n-alkyl-hydroxy polymers
AssigneeInternational Business Machines Corporation
InventorsJames Hedrick, Dylan Boday, Jeannette Garcia, Rudy Wojtecki, Yi Yan Yang, Chuan Yang
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Abstract
The disclosure describes methods and therapeutic compositions comprising polymers modified with N-alkyl-hydroxy groups comprising one or more carbon atoms. The compositions are useful for gene delivery, and exhibit broad-spectrum antiviral activity and low toxicity in vitro.
Claims14
A therapeutic composition, comprising:
- at least one polymer comprising:
- alkyl-hydroxy groups,
- amine groups located at the ends of the polymer chain, the polymer chain having a number average molecular weight of from about 5,000 Da to about 20,000 Da,
- secondary amine groups integrated into the polymer chain backbone,
- wherein:
- at least 5% of the amine groups located at the ends of the polymer chain comprise N-alkyl-hydroxy groups,
- at least a portion of the amine groups located at the ends of the polymer chain are saturated with N-alkyl-hydroxy groups, wherein each N-alkyl-hydroxy group comprises 1,2-diol,
- and
- the secondary amine groups integrated into the polymer chain backbone do not include N-alkyl-hydroxy groups.
6 more elements
A therapeutic composition, comprising:
- at least one polymer comprising:
- alkyl-hydroxy groups,
- amine groups located at the ends of the polymer chain, the polymer chain selected from the group consisting of polyethyleneimine, polyvinylamine, polyallylamine, polyamino acrylates, polyamino methacrylates, and copolymers and salts thereof, the polymer chain having a number average molecular weight of from 10,000 Da to about 20,000 Da,
- secondary amine groups integrated into the polymer chain backbone, wherein:
- at least 5% of the amine groups located at the ends of the polymer chain comprise N-alkyl-hydroxy groups,
- at least a portion of the amine groups located at the ends of the polymer chain are saturated with N-alkyl-hydroxy groups,
- at least a portion of the N-alkyl-hydroxy groups comprises a 1,2-diol, and
- the secondary amine groups integrated into the polymer chain backbone do not include N-alkyl-hydroxy groups.
5 more elements
Dependencies are inferred from the claim text.