CD73 inhibitors and pharmaceutical uses thereof
AssigneeRisen (Suzhou) Pharma Tech Co., Ltd.
InventorsJiasheng Lu, Jiamin Gu, Dongdong Wu, Gang Chen, Chengyong Sun, Xiang Ji, Lin Wang, Feng Zhou, Xiuchun Zhang, Xianqi Kong
Life of this patent
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Abstract
CD73 (also known as ecto-5′-nucleotidase) inhibitor compounds are provided, as well as compositions and uses thereof for treating or preventing CD73-associated or related diseases, disorders and conditions, including cancer- and immune-related disorders. CD73 inhibitor compounds include compounds having the structure set forth in Formula I and pharmaceutically acceptable esters or salts thereof.
Claims21
A compound of Formula I, or a pharmaceutically acceptable ester or salt thereof:
- where:
- W is oxygen, sulfur, nitrogen, or a methylene group;
- X is a moiety selected from phosphonyl (—P(═O)(OR)—), sulfonyl (—S(═O)2—), and carbonyl (—C(═O)—), where R is a hydrogen, an ester-forming group, or a protecting group;
- Y is selected from phosphonate (—PO3R2), sulfonate (—SO3R), and carboxylate (—CO2R), where R is a hydrogen, an ester-forming group, or a protecting group;
- R1 is a hydroxyl group or a hydrogen;
- R2 is chlorine or a hydrogen;
- and
- R3 and R4 are independently selected from a hydrogen, an alkyl group, an alkenyl group and an alkynyl group, where at least one of R3 and R4 has 11 to 30 carbon atoms;
- or
- R3 and R4 are independently selected from a hydrogen and a ring system which is a bicycle, tricycle, spiral-ring, fused-ring, or bridged-ring containing a carbocyclic or a heterocyclic ring system, the carbocyclic ring system being aromatic or non-aromatic, provided that R3 and R4 are not both hydrogen.
A compound of Formula IX, or a pharmaceutically acceptable salt or ester thereof:
- where:
- R is a hydrogen, an ester-forming group, or a protecting group;
- R1 is a hydroxyl group or a hydrogen;
- R2 is a hydrogen or a chlorine;
- and
- R3 is a hydrogen or a lower alkyl, and
- R4 is a group containing an adamantyl moiety or a group containing a naphthyl moiety;
- or
- R3, R4, and the nitrogen atom to which they are attached form a fused tricycle or a spiral-ring structure.
A compound which is:
- or a pharmaceutically acceptable salt or ester thereof.
Dependencies are inferred from the claim text.