Conjugate including core and sialic acid or derivative thereof bound to surface of core and use thereof
AssigneesKabio R&D SOO Co., Ltd., Rensselaer Polytechnic Institute
InventorsJong Hwan Kwak, Seok-Joon Kwon, Robert J. Linhardt, Jonathan S. Dordick, Fuming Zhang
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Abstract
Provided are a conjugate including a core and sialic acids or derivatives thereof bound to the surface of the core, and use thereof. The conjugate provided in the present invention binds with hemagglutinin on the surface of influenza virus to inhibit the course of infection of influenza virus, thereby preventing or treating infection of influenza virus and also preventing or treating infection of influenza virus resistant to antiviral agents. Accordingly, the conjugate may be widely used in the development of prophylactic or therapeutic agents for influenza virus infection.
Claims15
A conjugate comprising a core and ligands bound to the surface of the core, the core including polyamidoamine and each of the ligands being a sialic acid derivative, wherein:
- the core is a fourth-generation (G4) dendrimer and
- the ligands are arranged with spacing of 2.0 nm to 3.1 nm on the surface of the core, or
- 20 to 31 of the ligands are bound to the surface of the core;
- or
- the core is a fifth-generation (G5) dendrimer and
- the ligands are arranged with spacing of 1.6 nm to 2.4 nm on the surface of the core, or
- 37 to 56 of the ligands are bound to the surface of the core;
- and the sialic acid derivative is sialyloligosaccharide or sialyllactose.
Dependencies are inferred from the claim text.