Pharmaceutical tetracycline composition for dermatological use
AssigneeBioPharmX, Inc.
InventorsXin Chen, Maiko C. Hermsmeier, Diana Lac, Douglas W. Thomas, Noymi Yam, Akira Yamamoto
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Abstract
Provided herein is a topical composition and related methods for making and using the composition. In a first aspect, the topical composition comprises minocycline, a magnesium salt, and a sulfite compound in a non-aqueous solvent. In yet another aspect, the topical composition comprises a tetracycline-class drug, a source of magnesium, a monohydric aliphatic alcohol, and a polyol, wherein (i) the ratio between the monohydric aliphatic alcohol and the propylene glycol is in the range of 1:1 to 99:1 by weight and (ii) the tetracycline-class drug is dissolved in the topical composition.
Claims19
A topical composition, comprising:
- between about 0.7% to about 2.5% by weight minocycline,
- between about 0.8% to about 2.6% by weight of a divalent cation, selected from the group consisting of a magnesium cation, a calcium cation, an aluminum cation, and a zinc cation,
- between about 0.1% to about 0.3% by weight of a sulfite compound, selected from the group consisting of a sulfite salt, a metabisulfite salt, and a bisulfite salt, and
- a solvent system comprising ethanol, propylene glycol, and cineole;
- wherein the minocycline is dissolved in the composition.
Dependencies are inferred from the claim text.