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US 10,881,669 B2Granted
Inhibitors of the plasmodial surface anion channel as antimalarials
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsSanjay A. Desai, Ajay D. Pillai
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Abstract
Disclosed are inhibitors of the plasmodial surface anion channel (PSAC) inhibitors and the use thereof in treating or preventing malaria in an animal such as a human, comprising administering an effective amount of an inhibitor or a combination of inhibitors. An example of such an inhibitor is a compound of formula I, or a pharmaceutically acceptable salt thereof, wherein R1 to R7 are as described herein.
Claims9
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and
- (i) a compound selected from:
- wherein the pharmaceutical composition is a formulation suitable for oral administration selected from capsules, sachets, tablets, lozenges, and troches, each containing a predetermined amount of the compound as solid or as granules.
Dependencies are inferred from the claim text.