Selective PFKFB4 inhibitors for the treatment of cancer

A method of treating cancer in a subject in need of treatment thereof, the method comprising administering to the subject an effective amount of a compound selected from Formula (IV):

• wherein:
• n is 2-6;
• R1 is methyl sulfamide, carboxylic acid methyl ester, hydroxide, nitrate, or tert-butyl carbamate;
• R2 can be present or absent, and when present is a C1-C5 alkyl;
• R3 can be present or absent, and when present is a C1-C5 alkoxy, chloride, or hydrogen;
• and
• wherein if R2 is present and located on the nitrogen of the quinoline group, then the nitrogen has a positive charge, and
• wherein the cancer is selected from breast cancer, lung cancer, colon cancer, and prostate cancer.