Therapeutic agent or preventive agent for alopecia areata
AssigneeToray Industries, Inc.
InventorsRie Sasaki, Shinnosuke Hayashi, Martial Vallet, Shinya Yokosaka, Kazuya Osumi, Takumi Aoki, Hiroyuki Meguro, Mie Kaino, Kozue Takagaki, Takehiro Takahashi
Life of this patent
Estimating the term…
Abstract
A therapeutic agent or a preventive agent for alopecia areata has an RORγ antagonistic activity, and, there is a therapeutic agent or a preventive agent for alopecia areata, including a cyclic amine derivative typified by the following compound or a pharmacologically acceptable salt thereof as an active ingredient.
Claims8
A method of treating or preventing alopecia areata, comprising administering to an individual in need thereof a cyclic amine derivative represented by general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient:
- wherein
- R1 represents an alkyloxy group having 1 to 3 carbon atoms, any 1 to 3 hydrogen atoms of which are optionally substituted with a halogen atom(s),
- R2 represents a halogen atom,
- R3 represents a hydrogen atom, a halogen atom, or a hydroxy group,
- R4 represents a hydrogen atom or a halogen atom,
- X represents —C(═O)—(CH2)n—R5 or —S(═O)2—R6,
- n represents an integer of 0 to 5,
- R5 represents a hydrogen atom, —OR7, —SR7, —S(═O)2—R7, —N(R7)R8, an alkyl group having 1 to 3 carbon atoms, any 1 to 3 hydrogen atoms of which are optionally substituted with a halogen atom(s), or a heteroaryl group, any hydrogen atom(s) of which is/are optionally substituted with an alkyl group(s) having 1 to 3 carbon atoms,
- R6 represents an alkyl group having 1 to 5 carbon atoms,
- R7 represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, any 1 to 3 hydrogen atoms of which are optionally substituted with a halogen atom(s), and
- R8 represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, an acyl group having 2 to 4 carbon atoms, or an alkylsulfonyl group having 1 to 3 carbon atoms.
Dependencies are inferred from the claim text.