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AssigneeChiesi Farmaceutici S.p.A.
InventorsEdward C. Spindler, Jr., Loretta M. Itri, Gregory Williams, Ming-yi Hu
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Methods for controlling, maintaining, or reducing blood pressure, and/or for treating, preventing, or alleviating symptoms such as dyspnea, in a patient suffering from or susceptible to acute heart failure. The methods involve the administration of an effective amount of a pharmaceutical composition comprising a short acting dihydropyridine compound such as clevidipine. The pharmaceutical composition may be administered at an initial dose, and if blood pressure is not controlled or maintained within a target blood pressure range or reduced to within a target blood pressure range, the initial dose may be titrated to achieve a blood pressure within the target blood pressure range. The patient may have a systolic blood pressure of about 120 mmHg or above.
A method of reducing dyspnea in a patient in need thereof, wherein the patient has acute heart failure and is initially normotensive as determined by the patient's baseline systolic blood pressure, the method comprising only administering a pharmaceutical composition comprising only one active pharmaceutical ingredient, wherein the only one active pharmaceutical ingredient is clevidipine, to the patient.
Dependencies are inferred from the claim text.