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US 10,881,644 B2Granted
Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
AssigneeLutonix, Inc.
InventorLixiao Wang
Life of this patent
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Abstract
Embodiments of the present invention provide a method for treatment of respiratory disorders such as asthma, chronic obstructive pulmonary disease, and chronic sinusitis, including cystic fibrosis, interstitial fibrosis, chronic bronchitis, emphysema, bronchopulmonary dysplasia and neoplasia. The method involves administration, preferably oral, nasal or pulmonary administration, of anti-inflammatory and anti-proliferative drugs (rapamycin or paclitaxel and their analogues) and an additive.
Claims11
A balloon catheter comprising:
- a coating layer overlying an exterior surface of the balloon catheter;
- and
- an adherent layer between the exterior surface and the coating layer,
- wherein:
- the balloon catheter is sized and configured for insertion into a passage of a respiratory system;
- the coating layer comprises a water insoluble drug and a combination of a first additive and a second additive;
- the water insoluble drug is chosen from paclitaxel and rapamycin;
- the first additive is PEG-20 sorbitan monolaurate;
- and
- the second additive is gluconolactone.
7 more elements
A method for treating a respiratory system, the method comprising:
- inserting into an airway a balloon catheter comprising a coating layer overlying an exterior surface of the balloon catheter and an adherent later between the exterior surface and the coating layer, wherein:
- the coating layer comprises a drug, a first additive, and a second additive;
- the drug is chosen from paclitaxel and rapamycin,
- the first additive is PEG-20 sorbitan monolaurate;
- and
- the second additive is gluconolactone;
- inflating the balloon catheter and releasing the drug to a wall of the airway;
- deflating the balloon;
- and
- withdrawing the balloon catheter from the airway.
7 more elements
Dependencies are inferred from the claim text.