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US 10,881,643 B2Granted
Sphingosine pathway modulating compounds for the treatment of cancers
AssigneeEnzo Biochem, Inc.
InventorsElazar Rabbani, James J. Donegan
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Abstract
The invention provides methods and compositions for treating cancers and myeloproliferative disorders using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.
Claims8
A method for treating pancreatic cancer in a mammalian subject, comprising the step of:
- coadministering to a mammalian subject in need of treatment for pancreatic cancer
- (i) a therapeutically effective amount of ozanimod or a pharmaceutically acceptable salt thereof;
- and
- (ii) a therapeutically effective amount of the compound
- or a pharmaceutically acceptable salt thereof.
2 more elements
Dependencies are inferred from the claim text.