Dihydroartemisinin-steroid conjugate and preparation method and application thereof
AssigneeYunbaiyao Zhengwu Science and Technology (Shanghai) Co., Ltd.
InventorsJinghua Zhang, Zhengwu Shen
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Abstract
Described is a dihydroartemisinin-steroid conjugate of formula (I), or a pharmaceutically acceptable salt thereof, where position 10 of dihydroartemisinin is linked to the steroid through a linker X. This application further provides a preparation method of the dihydroartemisinin-steroid conjugate and an application of the dihydroartemisinin-steroid conjugate in the preparation of a drug for treating cancer. The dihydroartemisinin-steroid conjugate of the invention exhibits potent inhibitory activity against various tumor cells and low cytotoxicity, moreover, the conjugate is capable of penetrating the blood-brain barrier, having a broad application prospect.
Claims3
A dihydroartemisinin-steroid conjugate or a pharmaceutically-acceptable salt thereof, the dihydroartemisinin-steroid conjugate being selected from the group consisting of:
A pharmaceutical composition comprising the dihydroartemisinin-steroid conjugate of claim I or a pharmaceutically-acceptable salt thereof and a pharmaceutically-acceptable carrier.
Dependencies are inferred from the claim text.