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US 10,881,628 B2Granted
Receptor subtype and function selective retinoid and rexinoid compounds in combination with immune modulators for cancer immunotherapy
AssigneeIo Therapeutics, Inc.
InventorsRoshantha A. Chandraratna, Martin E. Sanders
Life of this patent
Estimating the term…
Abstract
Disclosed herein are methods for culturing CAR-modified immune cells with at least one Retinoic Acid Receptor and/or Retinoid X Receptor active agent.
Claims17
A method of expanding the number of CAR-MIC in vitro comprising culturing the CAR-MIC in a culture medium comprising retinoid means and/or rexinoid means (RAR/RXR means) for modulating production or activity of an immune system component.
Dependencies are inferred from the claim text.