Compositions, devices and methods for multi-stage release of chemotherapeutics
AssigneeBoston Scientific Scimed, Inc.
InventorsJavier Palomar-Moreno, Michelle Hannon, Phillip Bannister
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Abstract
In one aspect, the present disclosure provides microparticles that are configured to release a first drug over a first time period and to release a second drug over a second time period, wherein a lag period of substantially no drug release occurs between the first and second time periods. In other aspects, the present disclosure pertains to the use of such microparticles in delivery systems and methods of treatment. In another aspect, the present disclosure pertains to drug delivery systems that comprising a folded inflatable drug delivery balloon that comprises folds and microparticles positioned within the folds.
Claims33
A delivery system comprising:
- a delivery device configured to release microparticles into a feeder artery within a body of a subject, and
- microparticles that are configured to release a first drug over a first time period and to release a second drug over a second time period,
- wherein a lag period of substantially no drug release occurs between the first and second time periods, and wherein the first drug and the second drug may be the same or different,
- wherein the lag period ranges from 2 to 6 weeks, and wherein the first time period is a period of five days or less,
- wherein the second time is a period of five days or less, and
- wherein the microparticles comprise first microparticles that comprise the first drug but not the second drug which are configured for immediate release of the first drug over the first time period and second microparticles that comprise the second drug but not the first drug which configured for delayed release of the second drug over the second time period, the second microparticles comprising a bioerodible core that comprises the second drug surrounded by a first bioerodible layer which contains substantially no drug.
A delivery system comprising:
- a delivery device configured to release microparticles into a feeder artery within a body of a subject, and
- microparticles that are configured to release a first drug over a first time period and to release a second drug over a second time period,
- wherein a lag period of substantially no drug release occurs between the first and second time periods, and wherein the first drug and the second drug may be the same or different,
- wherein the lag period ranges from 2 to 6 weeks, and wherein the first time period is a period of five days or less,
- wherein the second time is a period of five days or less, and
- wherein the delivery device comprises a balloon.
Dependencies are inferred from the claim text.